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Music models aberrant rule decoding and reward valuation in dementia

Clark, CN; Golden, HL; McCallion, O; Nicholas, JM; Cohen, MH; Slattery, CF; Paterson, RW; ... Warren, JD; + view all (2018) Music models aberrant rule decoding and reward valuation in dementia. Social Cognitive and Affective Neuroscience , 13 (2) pp. 192-202. 10.1093/scan/nsx140. Green open access

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Abstract

Aberrant rule- and reward-based processes underpin abnormalities of socio-emotional behaviour in major dementias. However, these processes remain poorly characterised. Here we used music to probe rule decoding and reward valuation in patients with frontotemporal dementia syndromes and Alzheimer's disease relative to healthy age-matched individuals. We created short melodies that were either harmonically resolved ('finished') or unresolved ('unfinished'); the task was to classify each melody as finished or unfinished (rule processing) and rate its subjective pleasantness (reward valuation). Results were adjusted for elementary pitch and executive processing; neuroanatomical correlates were assessed using voxel-based morphometry. Relative to healthy older controls, patients with behavioural variant frontotemporal dementia showed impairments of both musical rule decoding and reward valuation, while patients with semantic dementia showed impaired reward valuation but intact rule decoding, patients with Alzheimer's disease showed impaired rule decoding but intact reward valuation and patients with progressive nonfluent aphasia performed comparably to healthy controls. Grey matter associations with task performance were identified in anterior temporal, medial and lateral orbitofrontal cortices, previously implicated in computing diverse biological and non-biological rules and rewards. The processing of musical rules and reward distils cognitive and neuroanatomical mechanisms relevant to complex socio-emotional dysfunction in major dementias.

Type: Article
Title: Music models aberrant rule decoding and reward valuation in dementia
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/scan/nsx140
Publisher version: http://doi.org/10.1093/scan/nsx140
Language: English
Additional information: © The Author (2017). Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Alzheimer’s disease, Music, emotion, frontotemporal dementia, reward
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10039805
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