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Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood

Anderson, EL; Fraser, A; Caleyachetty, R; Hardy, R; Lawlor, DA; Howe, LD; (2017) Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood. Child Abuse & Neglect , 76 pp. 138-148. 10.1016/j.chiabu.2017.10.015. Green open access

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Abstract

Studies assessing associations of childhood psychosocial adversity (e.g. sexual abuse, physical neglect, parental death), as opposed to socioeconomic adversity, with cardiovascular disease (CVD) risk factors in adulthood are scarce. The aim of this study is to assess associations of various types of psychosocial adversity and cumulative adversity in childhood, with multiple CVD risk factors in mid-life. At study enrolment, women from the Avon Longitudinal Study of Parents and Children (N=3612) retrospectively reported: lack of maternal care, maternal overprotection, parental mental illness, household dysfunction, sexual abuse, physical and emotional abuse, and neglect in childhood. Approximately 23 years later, body mass index (BMI), waist circumference, systolic and diastolic blood pressure, plasma glucose, insulin, triglycerides, low and high density lipoprotein cholesterol, C-reactive protein, carotid intima-media thickness (cIMT) and arterial distensibility were assessed (mean age 51 years). We examined associations of each specific type of psychosocial adversity and cumulative adversity with CVD risk factors. No specific type of psychosocial adversity was consistently associated with the CVD risk factors. There was evidence that a one standard deviation greater cumulative psychosocial adversity was associated with 0.51cm greater waist circumference (95% confidence interval [CI]: 0.02cm, 1.00cm, p=0.04) and a lower arterial distensibility, even after adjustment for age, ethnicity and childhood and adult socioeconomic position. We found no consistent evidence that any specific type of psychosocial adversity, or cumulative psychosocial adversity in childhood, is associated with CVD risk factors in adult women.

Type: Article
Title: Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.chiabu.2017.10.015
Publisher version: http://dx.doi.org/10.1016/j.chiabu.2017.10.015
Language: English
Additional information: © 2017 The Authors. Published by Elsevier Ltd. This article is published under Creative Commons licence Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Keywords: Adversity, Cardiovascular disease, Childhood, Psychosocial
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Social Research Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10038907
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