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Exogenous testosterone enhances cortisol and affective responses to social evaluative stress in dominant men

Knight, EL; Christian, CB; Morales, PJ; Harbaugh, WT; Mayr, U; Mehta, PH; (2017) Exogenous testosterone enhances cortisol and affective responses to social evaluative stress in dominant men. Psychoneuroendocrinology , 85 pp. 151-157. 10.1016/j.psyneuen.2017.08.014. Green open access

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Abstract

Stress often precedes the onset of mental health disorders and is linked to negative impacts on physical health as well. Prior research indicates that testosterone levels are related to reduced stress reactivity in some cases but correlate with increased stress responses in other cases. To resolve these inconsistencies, we tested the causal influence of testosterone on stress reactivity to a social-evaluative stressor. Further, prior work has failed to consider status-relevant individual differences such as trait dominance that may modulate the influence of testosterone on responses to stressors. Participants (n = 120 males) were randomly assigned to receive exogenous testosterone or placebo (n = 60 testosterone treatment group) via topical gel prior to a well-validated social-evaluative stressor. Compared to placebo, testosterone significantly increased cortisol and negative affect in response to the stressor, especially for men high in trait dominance (95% confidence intervals did not contain zero). The findings suggest that the combination of high testosterone and exposure to status-relevant social stress may confer increased risk for stress-mediated disorders, particularly for individuals high in trait dominance.

Type: Article
Title: Exogenous testosterone enhances cortisol and affective responses to social evaluative stress in dominant men
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.psyneuen.2017.08.014
Publisher version: https://doi.org/10.1016/j.psyneuen.2017.08.014
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, Neurosciences, Psychiatry, Neurosciences & Neurology, Testosterone, Stress, Cortisol, Trait dominance, Negative affect, PITUITARY-ADRENAL AXIS, HEALTHY-YOUNG MEN, PSYCHOSOCIAL STRESS, OLDER MEN, TRAIT DOMINANCE, SEX-HORMONES, DIGIT RATIO, WOMEN, BEHAVIOR, DEPRESSION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10037688
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