UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

A retrospective analysis of post transplant lymphoproliferative disorder following liver transplantation

Al Fararjeh, F; Mahmood, S; Tachtatzis, P; Yallop, D; Devereux, S; Patten, P; Agrawal, K; ... Kassam, S; + view all (2018) A retrospective analysis of post transplant lymphoproliferative disorder following liver transplantation. European Journal of Haematology , 100 (1) pp. 98-103. 10.1111/ejh.12988. Green open access

[thumbnail of Fararjeh_Retrospective_analysis_post_transplant.pdf]
Preview
Text
Fararjeh_Retrospective_analysis_post_transplant.pdf - Accepted Version

Download (292kB) | Preview

Abstract

OBJECTIVE: To evaluate response rates and survival in adults developing post-transplant lymphoproliferative disorder (PTLD) following liver transplantation METHODS: Patients were identified retrospectively and data collected through local liver and haematology electronic databases and pharmacy records. RESULTS: Forty-five patients were identified. The median age at first transplant and at development of PTLD was 48 and 54 years respectively, with the median time from transplant to PTLD diagnosis of 56 months. The majority of cases (76%) were monomorphic B-cell lymphomas and 36% of tumours were EBV positive. Treatment involved reduction in immune-suppression (RIS) in 30 (67%) with RIS the only treatment in 3. Ten (22%) patients were treated with rituximab alone, 13 (29%) with chemotherapy alone and 14 (31%) patients were treated with rituximab and chemotherapy. Twenty-six (58%) patients achieved a complete response (CR). At a median follow-up of 27 months the median overall survival (OS) was 50 months Response and OS were not associated with clinical factors or the use of rituximab. CONCLUSION: Outcomes reported in this study are favourable and comparable to those reported previously. The addition of rituximab did not appear to have improved outcomes in this series, although a significant proportion of patients were able to avoid chemotherapy.

Type: Article
Title: A retrospective analysis of post transplant lymphoproliferative disorder following liver transplantation
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/ejh.12988
Publisher version: http://dx.doi.org/10.1111/ejh.12988
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: liver transplant; non-Hodgkin lymphoma; PTLD; Rituximab
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10033861
Downloads since deposit
206Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item