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Modeling the contributions of chromosome segregation errors and aneuploidy to Saccharomyces hybrid sterility

Boynton, PJ; Janzen, T; Greig, D; (2018) Modeling the contributions of chromosome segregation errors and aneuploidy to Saccharomyces hybrid sterility. Yeast , 35 (1) pp. 85-98. 10.1002/yea.3282. Green open access

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Abstract

Errors in meiosis can be important postzygotic barriers between different species. In Saccharomyces hybrids, chromosomal missegregation during meiosis I produces gametes with missing or extra chromosomes. Gametes with missing chromosomes are inviable, but we do not understand how extra chromosomes (disomies) influence hybrid gamete inviability. We designed a model predicting rates of missegregation in interspecific hybrid meioses assuming several different mechanisms of disomy tolerance, and compared predictions from the model to observations of sterility in hybrids between Saccharomyces yeast species. Sterility observations were consistent with the hypothesis that chromosomal missegregation causes hybrid sterility, and the model indicated that missegregation probabilities of 13-50% per chromosome can cause observed values of 90-99% hybrid sterility regardless of how cells tolerate disomies. Missing chromosomes in gametes are responsible for most infertility, but disomies may kill as many as 11% of the gametes produced by hybrids between S. cerevisiae and S. paradoxus.

Type: Article
Title: Modeling the contributions of chromosome segregation errors and aneuploidy to Saccharomyces hybrid sterility
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/yea.3282
Publisher version: http://doi.org/10.1002/yea.3282
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Ascospore, Disomy, Hybrid, Meiosis, Postzygotic reproductive isolation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10027053
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