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Human hippocampal theta power indicates movement onset and distance travelled

Bush, D; Bisby, JA; Bird, CM; Gollwitzer, S; Rodionov, R; Diehl, B; McEvoy, AW; ... Burgess, N; + view all (2017) Human hippocampal theta power indicates movement onset and distance travelled. Proceedings of the National Academy of Sciences of the United States of America , 114 (46) pp. 12297-12302. 10.1073/pnas.1708716114. Green open access

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Abstract

Rodent hippocampal theta-band oscillations are observed throughout translational movement, implicating theta in the encoding of self-motion. Interestingly, increases in theta power are particularly prominent around movement onset. Here, we use intracranial recordings from epilepsy patients navigating in a desktop virtual reality environment to demonstrate that theta power is also increased in the human hippocampus around movement onset and throughout the remainder of movement. Importantly, these increases in theta power are greater both before and during longer paths, directly implicating human hippocampal theta in the encoding of translational movement. These findings help to reconcile previous studies of rodent and human hippocampal theta oscillations and provide additional insight into the mechanisms of spatial navigation in the human brain.

Type: Article
Title: Human hippocampal theta power indicates movement onset and distance travelled
Open access status: An open access version is available from UCL Discovery
DOI: 10.1073/pnas.1708716114
Publisher version: https://doi.org/10.1073/pnas.1708716114
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Theta, Hippocampus, Navigation, Spatial Memory, Intracranial EEG
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/10025859
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