Sartini, C;
Barry, SJE;
Whincup, P;
Wannamethee, SG;
Lowe, GDO;
Jefferis, BJ;
Lennon, L;
... Morris, RW; + view all
(2017)
Relationship between outdoor temperature and cardiovascular disease risk factors in older people.
European Journal of Preventive Cardiology
, 24
(4)
pp. 349-356.
10.1177/2047487316682119.
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Abstract
BACKGROUND: Previous studies demonstrated that lower outdoor temperatures increase the levels of established Cardiovascular Disease (CVD) risk factors, such as blood pressure and lipids. Whether or not low temperatures increase novel CVD risk factors levels is not well studied. The aim was to investigate associations of outdoor temperature with a comprehensive range of established and novel CVD risk factors in two large Northern European studies of older adults, in whom CVD risk is increased. DESIGN AND METHODS: Data came from the British Regional Heart Study (4252 men aged 60-79 years) and the PROspective Study of Pravastatin in the Elderly at Risk (5804 men and women aged 70-82 years). Associations between outdoor temperature and CVD risk factors were quantified in each study and then pooled using a random effects model. RESULTS: With a 5°C lower mean temperature, total cholesterol was 0.04 mmol/L (95% confidence Intervals (CI) 0.02; 0.07) higher, LDL cholesterol was 0.02 mmol/L (95%CI 0.01; 0.05) higher and SBP was 1.12 mm Hg (95%CI 0.60,1.64) higher. Among novel CVD risk factors, C-reactive protein was 3.3% (95%CI 1.0; 5.6%) higher, Interleukin-6 was 2.7% (95%CI 1.1; 4.3%) higher, and Vitamin D was 11.2% (95%CI 1.0; 20.4%) lower. CONCLUSIONS: Lower outdoor temperature was associated with adverse effects on cholesterol, blood pressure, circulating inflammatory markers, and Vitamin D in two older populations. Public health approaches to protect the elderly against low temperatures could help in reducing the levels of several CVD risk factors.
| Type: | Article |
|---|---|
| Title: | Relationship between outdoor temperature and cardiovascular disease risk factors in older people |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/2047487316682119 |
| Publisher version: | http://dx.doi.org/10.1177/2047487316682119 |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
| Keywords: | Biomarkers, outdoor temperature, older adults, cardiovascular disease risk factors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1528723 |
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