Kim, MJ;
Turner, CM;
Hewitt, R;
Smith, J;
Bhangal, G;
Pusey, CD;
Unwin, RJ;
(2014)
Exaggerated renal fibrosis in P2X4 receptor-deficient mice following unilateral ureteric obstruction.
Nephrol Dial Transplant
, 29
(7)
pp. 1350-1361.
10.1093/ndt/gfu019.
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Abstract
The ATP-sensitive P2X7 receptor (P2X7R) has been shown to contribute to renal injury in nephrotoxic nephritis, a rodent model of acute glomerulonephritis, and in unilateral ureteric obstruction (UUO), a rodent model of chronic interstitial inflammation and fibrosis. Renal tubular cells, endothelial cells and macrophages also express the closely related P2X4 receptor (P2X4R), which is chromosomally co-located with P2X7R and has 40% homology; it is also pro-inflammatory and has been shown to interact with P2X7R to modulate its pro-apoptotic and pro-inflammatory effects. Therefore, we chose to explore the function of P2X4R in the UUO model of renal injury using knockout mice. We hypothesized that UUO-induced tubulointerstitial damage and fibrosis would also be attenuated in P2X4R(-/-) mice.
| Type: | Article |
|---|---|
| Title: | Exaggerated renal fibrosis in P2X4 receptor-deficient mice following unilateral ureteric obstruction. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/ndt/gfu019 |
| Publisher version: | http://dx.doi.org/10.1093/ndt/gfu019 |
| Additional information: | © The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | P2X4 receptor, TGF-β, connective tissue growth factor, renal fibrosis, unilateral ureteric obstruction |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1423893 |
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