Campan, M;
Moffitt, M;
Houshdaran, S;
Shen, H;
Widschwendter, M;
Daxenbichler, G;
Long, T;
... Laird, PW; + view all
(2011)
Genome-scale screen for DNA methylation-based detection markers for ovarian cancer.
PLOS One
, 6
(12)
, Article e28141. 10.1371/journal.pone.0028141.
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Abstract
The identification of sensitive biomarkers for the detection of ovarian cancer is of high clinical relevance for early detection and/or monitoring of disease recurrence. We developed a systematic multi-step biomarker discovery and verification strategy to identify candidate DNA methylation markers for the blood-based detection of ovarian cancer.
| Type: | Article |
|---|---|
| Title: | Genome-scale screen for DNA methylation-based detection markers for ovarian cancer. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0028141 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0028141 |
| Language: | English |
| Additional information: | © 2011 Campan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported by the Ovarian Cancer Research Fund, grant PPD/USC.06, and National Institutes of Health and National Cancer Institute, grant R01-CA096958. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Keywords: | Blood Coagulation, CA-125 Antigen, CpG Islands, DNA, DNA Methylation, Epigenesis, Genetic, Female, Gene Expression Regulation, Neoplastic, Genome, Human, Genotype, Humans, Kinetics, Longitudinal Studies, Odds Ratio, Ovarian Neoplasms, Reproducibility of Results, Tumor Markers, Biological |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1335393 |
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