UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes

Wong, LH; Gatta, AT; Levine, TP; (2019) Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes. Nature Reviews Molecular Cell Biology , 20 pp. 85-101. 10.1038/s41580-018-0071-5. Green open access

[thumbnail of Wong Gatta and Levine NRMCB2018 Final Submission (accepted).pdf]
Preview
Text
Wong Gatta and Levine NRMCB2018 Final Submission (accepted).pdf - Accepted Version

Download (1MB) | Preview

Abstract

Lipids are distributed in a highly heterogeneous fashion in different cellular membranes. Only a minority of lipids achieve their final intracellular distribution through transport by vesicles. Instead, the bulk of lipid traffic is mediated by a large group of lipid transfer proteins (LTPs), which move small numbers of lipids at a time using hydrophobic cavities that stabilize lipid molecules outside membranes. Although the first LTPs were discovered almost 50 years ago, most progress in understanding these proteins has been made in the past few years, leading to considerable temporal and spatial refinement of our understanding of the function of these lipid transporters. The number of known LTPs has increased, with exciting discoveries of their multimeric assembly. Structural studies of LTPs have progressed from static crystal structures to dynamic structural approaches that show how conformational changes contribute to lipid handling at a sub-millisecond timescale. A major development has been the finding that many intracellular LTPs localize to two organelles at the same time, forming a shuttle, bridge or tube that links donor and acceptor compartments. The understanding of how different lipids achieve their final destination at the molecular level allows a better explanation of the range of defects that occur in diseases associated with lipid transport and distribution, opening up the possibility of developing therapies that specifically target lipid transfer.

Type: Article
Title: Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41580-018-0071-5
Publisher version: https://doi.org/10.1038/s41580-018-0071-5
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Carrier proteins, Membrane lipids, Membrane trafficking
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10062133
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item