Lalanne, T;
Oyrer, J;
Farrant, M;
Sjöström, PJ;
(2018)
Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors.
Frontiers in Synaptic Neuroscience
, 10
, Article 34. 10.3389/fnsyn.2018.00034.
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Abstract
Calcium-permeable (CP) AMPA-type glutamate receptors (AMPARs) are known to mediate synaptic plasticity in several different interneuron (IN) types. Recent evidence suggests that CP-AMPARs are synapse-specifically expressed at excitatory connections onto a subset of IN types in hippocampus and neocortex. For example, CP-AMPARs are found at connections from pyramidal cells (PCs) to basket cells (BCs), but not to Martinotti cells (MCs). This synapse type-specific expression of CP-AMPARs suggests that synaptic dynamics as well as learning rules are differentially implemented in local circuits and has important implications not just in health but also in disease states such as epilepsy.
| Type: | Article |
|---|---|
| Title: | Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnsyn.2018.00034 |
| Publisher version: | http://doi.org/10.3389/fnsyn.2018.00034 |
| Language: | English |
| Additional information: | Copyright © 2018 Lalanne, Oyrer, Farrant and Sjöström. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | AMPAR, NMDAR, neocortex, hippocampus, parvalbumin, somatostatin, interneuron, synapse-type-specific plasticity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10060963 |
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