Davy, T;
Castellano, S;
(2018)
The genomics of selenium: Its past, present and future.
Biochimica et Biophysica Acta (BBA) - General Subjects
, 1862
(11)
pp. 2427-2432.
10.1016/j.bbagen.2018.05.020.
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Abstract
In the last two decades, genomic analyses have enriched the study of the biology of selenium in many ways. These include the identification of selenoproteins in prokaryotic and eukaryotic genomes, the discovery of genetic variants that mediate humans and other vertebrates' adaptations to their selenium nutritional histories, and the association of specific genotypes with common and rare human selenium disorders. We briefly review these computational, evolutionary and association studies and their contribution to the genomics of selenium, selenocysteine and selenoproteins in the 200th anniversary of the discovery of this trace element.
| Type: | Article |
|---|---|
| Title: | The genomics of selenium: Its past, present and future |
| Location: | Stockholm, SWEDEN |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bbagen.2018.05.020 |
| Publisher version: | https://doi.org/10.1016/j.bbagen.2018.05.020 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Selenium, Genomics, Gene prediction, Adaptation, Common disease, Rare disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10058456 |
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