Ouzegdouh, Y;
Capron, C;
Bauer, T;
Puymirat, E;
Diehl, JL;
Martin, JF;
Cramer-Bordé, E;
(2018)
The physical and cellular conditions of the human pulmonary circulation enable thrombopoesis.
Experimental Hematology
, 63
pp. 22-27.
10.1016/j.exphem.2018.04.001.
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Abstract
Animal evidence that platelet production occurs in the lungs is growing [1]. We have investigated whether there is evidence to support pulmonary platelet production from studies using human conditions. We documented the presence of MK in the human pulmonary circulation and analysed the role of the vascular microenvironment on MK function. Our results suggest that the endothelial microenvironment favors platelet formation and that von Willebrand factor combined with appropriate physical forces in flowing blood are determinant for platelet release. We also demonstrate that MKs have the potential to change ploidy as they circulate. These findings demonstrate a new pathophysiological environment affecting platelet production. They also provide new targets for therapeutic intervention.
| Type: | Article |
|---|---|
| Title: | The physical and cellular conditions of the human pulmonary circulation enable thrombopoesis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.exphem.2018.04.001 |
| Publisher version: | https://doi.org/10.1016/j.exphem.2018.04.001 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Pulmonary circulation, Von Willebrand factor, Megakaryocytes, Ploidy, Platelet production, Shear forces, Endothelial cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10047449 |
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