Petzold, A.;
Eikelenboom, M.J.;
Keir, G.;
Polman, C.H.;
Uitdehaag, B.M.J.;
Thompson, E.J.;
Giovannoni, G.;
(2006)
The new Global Multiple Sclerosis Severity Score (MSSS) correlates with axonal but not glial biomarkers.
Multiple Sclerosis
, 12
(3)
pp. 325-328.
10.1191/135248505ms1277oa.
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Abstract
This study investigated whether the new Global Multiple Sclerosis Severity Scale (MSSS) correlated with cerebrospinal fluid biomarkers for axonal and glial pathology. The MSSS correlated with the phosphorylated neurofilament heavy chain (NfH-SMI35, R=0.44, P=0.016). The degree of neurofilament phosphorylation (ratio NfH-SMI34 to NfH-SMI35) was 8-fold higher in severely (median MSSS 6.5) versus mildly (MSSS 3.2) disabled patients (7.3 versus 0.9, P=0.03). The MSSS may provide a statistically powerful tool for comparing overall disease severity and be useful for validating the biomarker concept in MS.
| Type: | Article |
|---|---|
| Title: | The new Global Multiple Sclerosis Severity Score (MSSS) correlates with axonal but not glial biomarkers |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1191/135248505ms1277oa |
| Publisher version: | http://dx.doi.org/10.1191/135248505ms1277oa |
| Language: | English |
| Additional information: | © 2006 Edward Arnold (Publishers) Ltd |
| Keywords: | Biomarker, MSSS, multiple sclerosis |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/18942 |
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