David, AL;
Ashcroft, R;
(2009)
Placental gene therapy.
Obstetrics, Gynaecology & Reproductive Medicine
, 19
(10)
pp. 296-298.
10.1016/j.ogrm.2009.06.002.
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Abstract
Gene therapy uses genetic material as a drug delivery vehicle to express therapeutic proteins. Placental gene therapy may be useful for correction of two important obstetric conditions, foetal growth restriction and pre-eclampsia in which there is a failure of the physiological trophoblast remodelling of the uterine spiral arteries in early pregnancy. The patient in this scenario is the foetus. Placental gene therapy might be justifiable when: there is reasonable certainty that the foetus will suffer irreversible and substantial harm without the intervention; the intervention is safe and effective; the risk to the health of the mother is negligible; and the mother can give informed consent to the intervention.
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