UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice research database

Petersen, I.; Johnson, A.M.; Islam, A.; Duckworth, G.; Livermore, D.M.; Hayward, A.C.; (2007) Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice research database. British Medical Journal , 335 (7627) pp. 982-984. 10.1136/bmj.39345.405243.BE. Green open access

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
327Kb

Abstract

Objective: To determine the extent to which antibiotics reduce the risk of serious complications after common respiratory tract infections. Design: Retrospective cohort study. Setting: UK primary care practices contributing to the general practice research database. Data source: 3.36 million episodes of respiratory tract infection. Main outcome measures: Risk of serious complications in treated and untreated patients in the month after diagnosis: mastoiditis after otitis media, quinsy after sore throat, and pneumonia after upper respiratory tract infection and chest infection. Number of patients needed to treat to prevent one complication. Results: Serious complications were rare after upper respiratory tract infections, sore throat, and otitis media, and the number needed to treat was over 4000. The risk of pneumonia after chest infection was high, particularly in elderly people, and was substantially reduced by antibiotic use, with a number needed to treat of 39 for those aged 65 and 96-119 in younger age groups. Conclusion: Antibiotics are not justified to reduce the risk of serious complications for upper respiratory tract infection, sore throat, or otitis media. Antibiotics substantially reduce the risk of pneumonia after chest infection, particularly in elderly people in whom the risk is highest.

Type:Article
Title:Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice research database
Open access status:An open access version is available from UCL Discovery
DOI:10.1136/bmj.39345.405243.BE
Publisher version:http://dx.doi.org/10.1136/bmj.39345.405243.BE
Language:English
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > Primary Care and Population Health
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > CHIME

View download statistics for this item

Archive Staff Only: edit this record