Fischer, P;
Pogosyan, A;
Herz, DM;
Cheeran, B;
Green, AL;
Fitzgerald, J;
Aziz, TZ;
... Tan, H; + view all
(2017)
Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition.
eLife
, 6
, Article 23947. 10.7554/eLife.23947.
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Abstract
Gamma activity in the subthalamic nucleus (STN) is widely viewed as a pro-kinetic rhythm. Here we test the hypothesis that rather than being specifically linked to movement execution, gamma activity reflects dynamic processing in this nucleus. We investigated the role of gamma during fast stopping and recorded scalp electroencephalogram and local field potentials from deep brain stimulation electrodes in 9 Parkinson's disease patients. Patients interrupted finger tapping (paced by a metronome) in response to a stop-signal sound, which was timed such that successful stopping would occur only in ~50% of all trials. STN gamma (60-90 Hz) increased most strongly when the tap was successfully stopped, whereas phase-based connectivity between the contralateral STN and motor cortex decreased. Beta or theta power seemed less directly related to stopping. In summary, STN gamma activity may support flexible motor control as it did not only increase during movement execution but also during rapid action-stopping.
| Type: | Article |
|---|---|
| Title: | Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7554/eLife.23947 |
| Publisher version: | http://dx.doi.org/10.7554/eLife.23947 |
| Language: | English |
| Additional information: | © 2017, Fischer et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
| Keywords: | Parkinson's disease, basal ganglia, finger tapping, human, motor inhibition, neuroscience, stop signal, stopping |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1568379 |
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