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The Heterocellular Emergence of Colorectal Cancer.

Tape, CJ; (2017) The Heterocellular Emergence of Colorectal Cancer. Trends Cancer , 3 (2) pp. 79-88. 10.1016/j.trecan.2016.12.004. Green open access

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Abstract

Tissues contain multiple different cell types and can be considered to be heterocellular systems. Signaling between different cells allows tissues to achieve phenotypes that no cell type can achieve in isolation. Such emergent tissue-level phenotypes can be said to 'supervene upon' heterocellular signaling. It is proposed here that cancer is also an emergent phenotype that supervenes upon heterocellular signaling. Using colorectal cancer (CRC) as an example, I review how heterotypic cells differentially communicate to support emergent malignancy. Studying tumors as integrated heterocellular systems - rather than as solitary expansions of mutated cells - may reveal novel ways to treat cancer.

Type: Article
Title: The Heterocellular Emergence of Colorectal Cancer.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.trecan.2016.12.004
Publisher version: https://doi.org/10.1016/j.trecan.2016.12.004
Language: English
Additional information: © 2016 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/1563660
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