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Autobiographical memory: A candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment

McCrory, EJ; Puetz, V; Maguire, E; Mechelli, A; Palmer, A; Gerin, M; Kelly, P; ... Viding, E; + view all (2017) Autobiographical memory: A candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment. British Journal of Psychiatry , 211 (4) pp. 216-222. 10.1192/bjp.bp.117.201798. Green open access

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Abstract

BACKGROUND: Altered autobiographical memory (ABM) functioning has been implicated in the pathogenesis of depression and post-traumatic stress disorder and may represent one mechanism by which childhood maltreatment elevates psychiatric risk. AIMS: To investigate the impact of childhood maltreatment on ABM functioning. METHOD: Thirty-four children with documented maltreatment and 33 matched controls recalled specific ABMs in response to emotionally-valenced cue words during functional magnetic resonance imaging (fMRI). RESULTS: Children with maltreatment experience showed reduced hippocampal and increased middle temporal and para-hippocampal activation during positive ABM recall compared to peers. During negative ABM recall they exhibited increased amygdala activation, and greater amygdala connectivity with the salience network. CONCLUSIONS: Childhood maltreatment is associated with altered ABM functioning, specifically reduced activation in areas encoding specification of positive memories, and greater activation of the salience network for negative memories. This pattern may confer latent vulnerability to future depression and post-traumatic stress disorder.

Type: Article
Title: Autobiographical memory: A candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment
Open access status: An open access version is available from UCL Discovery
DOI: 10.1192/bjp.bp.117.201798
Publisher version: http://doi.org/10.1192/bjp.bp.117.201798
Language: English
Additional information: © The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/1563566
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