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Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment

Flores-Borja, F; Irshad, S; Gordon, P; Wong, F; Sheriff, I; Tutt, A; Ng, T; (2016) Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment. Journal of Immunology Research , Article 7803091. 10.1155/2016/7803091. Green open access

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Abstract

Our knowledge and understanding of the tumor microenvironment (TME) have been recently expanded with the recognition of the important role of innate lymphoid cells (ILC). Three different groups of ILC have been described based on their ability to produce cytokines that mediate the interactions between innate and adaptive immune cells in a variety of immune responses in infection, allergy, and autoimmunity. However, recent evidence from experimental models and clinical studies has demonstrated that ILC contribute to the mechanisms that generate suppressive or tolerant environments that allow tumor regression or progression. Defining the complex network of interactions and crosstalk of ILC with other immune cells and understanding the specific contributions of each type of ILC leading to tumor development will allow the manipulation of their function and will be important to develop new interventions and therapeutic strategies.

Type: Article
Title: Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/2016/7803091
Publisher version: http://dx.doi.org/10.1155/2016/7803091
Language: English
Additional information: © 2016 Fabian Flores-Borja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Immunology, INFLAMMATORY-BOWEL-DISEASE, REGULATORY T-CELLS, ROR-GAMMA, IN-VIVO, ADAPTIVE IMMUNITY, BREAST-CANCER, LUNG-CANCER, INFILTRATING LYMPHOCYTES, INTESTINAL INFLAMMATION, PROGNOSTIC-SIGNIFICANCE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/1550698
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