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Non-invasive optical monitoring of brain haemodynamics and metabolism following acute brain injury

Ghosh, A; (2017) Non-invasive optical monitoring of brain haemodynamics and metabolism following acute brain injury. Doctoral thesis , UCL (University College London). Green open access

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Abstract

Following acute brain injury (ABI), cellular hypoxia-ischaemia (CH-I) is central to the pathophysiological cascades that lead to death and neurological disability. Thus, a key tenet of neurocritical care is the avoidance of CH-I, and a key prerequisite to doing so is the availability of a bedside clinical monitor that can identify CH-I as it occurs. This thesis describes normal cerebral physiology, how this is deranged and clinically manipulated following ABI, and the use of near infrared spectroscopy (NIRS), a non- invasive optical technique, to monitor for CH-I in a variety of clinical contexts. I then present my work investigating the use of NIRS, with an emphasis on the measurement of the oxidation state of cytochrome c oxidase (CCO), in healthy volunteers who are subjected to a variety of challenges designed to manipulate cerebral oxygen delivery with both isovolaemic and hyper/hypovolaemic challenges. Finally, I describe experiments in a cohort of a patients who have suffered from ABI, manipulating cerebral oxygen delivery by means of normobaric hyperoxia. The results suggest that the measurement of CCO with NIRS in patients with ABI provides a useful adjunct to established monitors of cerebral haemodynamics and metabolism; an in-depth discussion of the observed changes in different haemodynamic and metabolic parameters, and their relevance to normal physiology and pathophysiology of ABI is carried out.

Type: Thesis (Doctoral)
Title: Non-invasive optical monitoring of brain haemodynamics and metabolism following acute brain injury
Event: UCL (University College London)
Open access status: An open access version is available from UCL Discovery
Language: English
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
URI: http://discovery.ucl.ac.uk/id/eprint/1546575
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