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Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective

Azevedo, C; Saiardi, A; (2017) Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective. Trends in Biochemical Sciences , 42 (3) pp. 219-231. 10.1016/j.tibs.2016.10.008. Green open access

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Abstract

Phosphate, as a cellular energy currency, essentially drives most biochemical reactions defining living organisms, and thus its homeostasis must be tightly regulated. Investigation into the role of inositol pyrophosphates (PP-IPs) has provided a novel perspective on the regulation of phosphate homeostasis. Recent data suggest that metabolic and signaling interplay between PP-IPs, ATP, and inorganic polyphosphate (polyP) influences and is influenced by cellular phosphate homeostasis. Different studies have demonstrated that the SPX protein domain is a key component of proteins involved in phosphate metabolism. How PP-IPs control some aspects of phosphate homeostasis has become clearer with the recently acquired crystal structures of SPX domains. We review here recent studies on eukaryote phosphate homeostasis and provide insights into future research.

Type: Article
Title: Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tibs.2016.10.008
Publisher version: http://dx.doi.org/10.1016/j.tibs.2016.10.008
Language: English
Additional information: Copyright © 2016 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0
Keywords: SPX domain, inorganic polyphosphate, inositol pyrophosphates, metabolism, phosphate, signaling
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1530786
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