Fetsch, C;
Gaitzsch, J;
Messager, L;
Battaglia, G;
Luxenhofer, R;
(2016)
Self-Assembly of Amphiphilic Block Copolypeptoids - Micelles, Worms and Polymersomes.
Scientific Reports
, 6
, Article 33491. 10.1038/srep33491.
![[thumbnail of Battaglia_srep33491.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/text.png) |
Text
Battaglia_srep33491.pdf - Published Version Download (1MB) |
Abstract
Polypeptoids are an old but recently rediscovered polymer class with interesting synthetic, physico-chemical and biological characteristics. Here, we introduce new aromatic monomers, N-benzyl glycine N-carboxyanhydride and N-phenethyl glycine N-carboxyanhydride and their block copolymers with the hydrophilic polysarcosine. We compare their self-assembly in water and aqueous buffer with the self-assembly of amphiphilic block copolypeptoids with aliphatic side chains. The aggregates in water were investigated by dynamic light scattering and electron microscopy. We found a variety of morphologies, which were influenced by the polymer structure as well as by the preparation method. Overall, we found polymersomes, worm-like micelles and oligo-lamellar morphologies as well as some less defined aggregates of interconnected worms and vesicles. Such, this contribution may serve as a starting point for a more detailed investigation of the self-assembly behavior of the rich class of polypeptoids and for a better understanding between the differences in the aggregation behavior of non-uniform polypeptoids and uniform peptoids.
| Type: | Article |
|---|---|
| Title: | Self-Assembly of Amphiphilic Block Copolypeptoids - Micelles, Worms and Polymersomes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/srep33491 |
| Publisher version: | http://dx.doi.org/10.1038/srep33491 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, DILUTE AQUEOUS-SOLUTION, DIBLOCK COPOLYMER, DRUG-DELIVERY, TRIBLOCK COPOLYMER, VESICLES, MORPHOLOGIES, PH, POLYMERIZATION, POLYPEPTOIDS, THERAPEUTICS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1520004 |
Archive Staff Only
 |
View Item |
