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The physiological role of the brain GLP-1 system in stress

Holt, MK; Trapp, S; (2016) The physiological role of the brain GLP-1 system in stress. Cogent Biology , 2 (1) , Article 1229086. 10.1080/23312025.2016.1229086. Green open access

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Abstract

Glucagon-like peptide-1 (GLP-1) within the brain is a potent regulator of food intake and most studies have investigated the anorexic effects of central GLP-1. A range of brain regions have now been found to be involved in GLP-1 mediated anorexia, including some which are not traditionally associated with appetite regulation. However, a change in food intake can be indicative of not only reduced energy demand, but also changes in the organism's motivation to eat following stressful stimuli. In fact, acute stress is well-known to reduce food intake. Recently, more research has focused on the role of GLP-1 in stress and the central GLP-1 system has been found to be activated in response to stressful stimuli. The source of GLP-1 within the brain, the preproglucagon (PPG) neurons, are ideally situated in the brainstem to receive and relay signals of stress and our recent data on the projection pattern of the PPG neurons to the spinal cord suggest a potential strong link with the sympathetic nervous system. We review here the role of central GLP-1 in the regulation of stress responses and discuss the potential involvement of the endogenous source of GLP-1 within the brain, the PPG neurons.

Type: Article
Title: The physiological role of the brain GLP-1 system in stress
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/23312025.2016.1229086
Publisher version: https://doi.org/10.1080/23312025.2016.1229086
Language: English
Additional information: © 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. (http://creativecommons.org/licenses/by/4.0/)
Keywords: Food intake, glucagon-like peptide-1, hypothalamus-pituitary-adrenal axis, preproglucagon neurons, stress, sympathetic nervous system
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1515797
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