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Temperature and pressure tuneable swollen bicontinuous cubic phases approaching nature's length scales

Barriga, HMG; Tyler, AII; McCarthy, NLC; Parsons, ES; Ces, O; Law, RV; Seddon, JM; (2015) Temperature and pressure tuneable swollen bicontinuous cubic phases approaching nature's length scales. Soft Matter , 11 (3) pp. 600-607. 10.1039/C4SM02343A. Green open access

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Abstract

Bicontinuous cubic structures offer enormous potential in applications ranging from protein crystallisation to drug delivery systems and have been observed in cellular membrane structures. One of the current bottlenecks in understanding and exploiting these structures is that cubic scaffolds produced in vitro are considerably smaller in size than those observed in biological systems, differing by almost an order of magnitude in some cases. We have addressed this technological bottleneck and developed a methodology capable of manufacturing highly swollen bicontinuous cubic membranes with length scales approaching those seen in vivo. Crucially, these cubic systems do not require the presence of proteins. We have generated highly swollen Im3m symmetry bicontinuous cubic phases with lattice parameters of up to 480 Å, composed of ternary mixtures of monoolein, cholesterol and negatively charged lipid (DOPS or DOPG) and we have been able to tune their lattice parameters. The swollen cubic phases are highly sensitive to both temperature and pressure; these structural changes are likely to be controlled by a fine balance between lipid headgroup repulsions and lateral pressure in the hydrocarbon chain region.

Type: Article
Title: Temperature and pressure tuneable swollen bicontinuous cubic phases approaching nature's length scales
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/C4SM02343A
Publisher version: http://dx.doi.org/10.1039/C4SM02343A
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/).
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/1508326
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