UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Multimodality hard-x-ray imaging of a chromosome with nanoscale spatial resolution

Yan, H; Nazaretski, E; Lauer, K; Huang, X; Wagner, U; Rau, C; Yusuf, M; ... Chu, YS; + view all (2016) Multimodality hard-x-ray imaging of a chromosome with nanoscale spatial resolution. Scientific Reports , 6 , Article 20112. 10.1038/srep20112. Green open access

[img] Text
Hanfei_srep20112.pdf - ["content_typename_Published version" not defined]

Download (812kB)

Abstract

We developed a scanning hard x-ray microscope using a new class of x-ray nano-focusing optic called a multilayer Laue lens and imaged a chromosome with nanoscale spatial resolution. The combination of the hard x-ray's superior penetration power, high sensitivity to elemental composition, high spatial-resolution and quantitative analysis creates a unique tool with capabilities that other microscopy techniques cannot provide. Using this microscope, we simultaneously obtained absorption-, phase-, and fluorescence-contrast images of Pt-stained human chromosome samples. The high spatial-resolution of the microscope and its multi-modality imaging capabilities enabled us to observe the internal ultra-structures of a thick chromosome without sectioning it.

Type: Article
Title: Multimodality hard-x-ray imaging of a chromosome with nanoscale spatial resolution
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/srep20112
Publisher version: http://www.nature.com/srep/2016/160205/srep20112/f...
Language: English
Additional information: Copyright © The Authors. Published by Nature Publishing Group (NPG). This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/1493304
Downloads since deposit
69Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item