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Effect of remote ischaemic conditioning on clinical outcomes in patients presenting with an ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Hausenloy, DJ; Kharbanda, R; Rahbek Schmidt, M; Møller, UK; Ravkilde, J; Okkels Jensen, L; Engstrøm, T; ... Bøtker, HE; + view all (2015) Effect of remote ischaemic conditioning on clinical outcomes in patients presenting with an ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. European Heart Journal , 36 (29) pp. 1846-1848. 10.1093/eurheartj/ehv249. Green open access

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Abstract

The rationale and study design for the multicentre, randomized, controlled CONDI2/ERIC-PPCI study are discussed. Ischaemic heart disease (IHD) is the leading cause of death and disability in Europe and worldwide. In patients presenting with an acute ST-elevation myocardial infarction (STEMI), early myocardial reperfusion using primary percutaneous coronary intervention (PPCI) is the most effective treatment for limiting myocardial infarct (MI) size and improving clinical outcomes. However, despite timely PPCI, the morbidity and mortality of STEMI patients remain significant—as such novel therapeutic strategies are required to reduce MI size in order to preserve left ventricular (LV) ejection fraction, prevent the onset of heart failure, and improve patient survival. In this respect, the heart can be protected against acute lethal ischaemia/reperfusion injury (IRI) by applying cycles of brief non-lethal ischaemia/reperfusion to an organ or tissue remote from the heart—a phenomenon called remote ischaemic conditioning (RIC).1–3 Interestingly, RIC can be induced non-invasively by simply inflating and deflating a blood pressure cuff placed on the upper arm, an intervention that has been reported to reduce MI size in several proof-of-concept clinical studies.4–10 Whether RIC can improve long-term clinical outcomes in this patient group is unknown and is the objective of the CONDI2/ERIC-PPCI study.

Type: Article
Title: Effect of remote ischaemic conditioning on clinical outcomes in patients presenting with an ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/eurheartj/ehv249
Publisher version: http://dx.doi.org/10.1093/eurheartj/ehv249
Language: English
Additional information: Copyright © The Author 2015. This is a pre-copyedited, author-produced PDF of an article accepted for publication in the European Heart Journal following peer review. The version of record Hausenloy, DJ; Kharbanda, R; Rahbek Schmidt, M; Møller, UK; Ravkilde, J; Okkels Jensen, L; Engstrøm, T; (2015) Effect of remote ischaemic conditioning on clinical outcomes in patients presenting with an ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. European Heart Journal , 36 (29) pp. 1846-1848. 10.1093/eurheartj/ehv249 is available online at: http://dx.doi.org/10.1093/eurheartj/ehv249
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/1488768
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