Cooper, R; Hebden, J; Everdell, N; Dempsey, L; Singh, H; Austin, T; (2016) The haemodynamic response to burst-suppressed and discontinuous EEG activity in infants with hypoxic ischaemic encephalopathy. Neurophotonics , 3 (3) , Article 031408. 10.1117/1.NPh.3.3.031408.

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Abstract

Burst suppression is an electroencephalographic state associated with a profound inactivation of the brain. Burst suppression and pathological discontinuous electroencephalography (EEG) are often observed in term-age infants with neurological injury and can be indicative of a poor outcome and lifelong disability. Little is known about the neurophysiological mechanisms of BS or how the condition relates to the functional state of the neonatal brain. In this study, we used simultaneous EEG and Diffuse Optical Tomography (DOT) to investigate whether bursts of EEG activity in infants with hypoxic ischaemic encephalopathy are associated with an observable cerebral haemodynamic response. We were able to identify significant changes in concentration of both oxy and de-oxyhaemoglobin that are temporally correlated with EEG bursts and present a relatively consistent morphology across six infants. Furthermore, DOT reveals patient-specific spatial distributions of this haemodynamic response that may be indicative of a complex pattern of cortical activation underlying discontinuous EEG activity that is not readily apparent in scalp EEG.

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