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Rapid evolution of the inter-sexual genetic correlation for fitness in Drosophila melanogaster

Collet, JM; Fuentes, S; Hesketh, J; Hill, MS; Innocenti, P; Morrow, EH; Fowler, K; (2016) Rapid evolution of the inter-sexual genetic correlation for fitness in Drosophila melanogaster. Evolution , 70 (4) pp. 781-795. 10.1111/evo.12892. Green open access

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Abstract

Sexual antagonism (SA) arises when male and female phenotypes are under opposing selection, yet genetically correlated. Until resolved, antagonism limits evolution towards optimal sex-specific phenotypes. Despite its importance for sex-specific adaptation and existing theory, the dynamics of SA resolution are not well understood empirically. Here, we present data from Drosophila melanogaster, compatible with a resolution of SA. We compared two independent replicates of the 'LHM' population in which SA had previously been described. Both had been maintained under identical, controlled conditions, and separated for around 200 generations. Although heritabilities of male and female fitness were similar, the inter-sexual genetic correlation differed significantly, being negative in one replicate (indicating SA) but close to zero in the other. Using population sequencing, we show that phenotypic differences were associated with population divergence in allele frequencies at non-random loci across the genome. Large frequency changes were more prevalent in the population without SA and were enriched at loci mapping to genes previously shown to have sexually antagonistic relationships between expression and fitness. Our data suggest that rapid evolution towards SA resolution has occurred in one of the populations and open avenues towards studying the genetics of SA and its resolution.

Type: Article
Title: Rapid evolution of the inter-sexual genetic correlation for fitness in Drosophila melanogaster
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/evo.12892
Publisher version: http://dx.doi.org/10.1111/evo.12892
Language: English
Additional information: Copyright © 2016 The Author(s). Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Adaptation; evolutionary genomics; fitness; population genetics; quantitative genetics; sexual conflict
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/1475576
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