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Glucocorticoid therapy for adrenal insufficiency: Nonadherence, concerns and dissatisfaction with information.

Chapman, SC; LLahana, S; Carroll, P; Horne, R; (2016) Glucocorticoid therapy for adrenal insufficiency: Nonadherence, concerns and dissatisfaction with information. Clinical Endocrinology , 84 (5) pp. 664-671. 10.1111/cen.12991. Green open access

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Abstract

OBJECTIVE: Appropriate self-management of glucocorticoid therapy (GC) is crucial for patients with adrenal insufficiency (AI). We aimed to describe patients' self-reported nonadherence to GC, evaluate perceived doubts about need for GC, concerns about adverse effects and dissatisfaction with information received about GC. DESIGN: Cross-sectional survey. PATIENTS: Patients prescribed GC for AI (n=81) from five European countries. MEASUREMENTS: Online survey including the Medication Adherence Report Scale (MARS), Beliefs about Medicines Questionnaire© (BMQ Specific, adapted for AI), and Satisfaction with Information about Medicines Scale© (SIMS). RESULTS: Most patients (85.2%) reported a degree of nonadherence to GC. The most frequent types of nonadherence concerned changing the timing of GC doses e.g. taking a dose later in the day than advised (37.0%). Few patients doubted their personal need for daily GC, but most reported high concerns about GC including potential weight gain (50.6%), osteoporosis (53.6%) and the continuing risk of adrenal crisis (50.6%). Dissatisfaction with information about GC was frequent, with participants particularly dissatisfied with the amount of information they had received about potential problems with GC. People who expressed dissatisfaction with information about GC, and concerns about its adverse effects were also more likely to report nonadherence (p<0.05). CONCLUSIONS: Nonadherence to treatment, concerns about potential adverse effects and dissatisfaction with the information provided about treatment were frequently reported by this European sample of AI patients. Many AI patients may need additional information about their GC and support to address concerns about GC and facilitate adherence. This article is protected by copyright. All rights reserved.

Type: Article
Title: Glucocorticoid therapy for adrenal insufficiency: Nonadherence, concerns and dissatisfaction with information.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/cen.12991
Publisher version: http://dx.doi.org/10.1111/cen.12991
Language: English
Additional information: © 2015 The Authors. Clinical Endocrinology Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Keywords: Adrenal insufficiency, adherence to medication, beliefs about medicines, glucocorticoid therapy, satisfaction with information
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy
URI: http://discovery.ucl.ac.uk/id/eprint/1474876
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