UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Overweight across the life course and adipokines, inflammatory and endothelial markers at age 60-64 years: evidence from the 1946 birth cohort

Murray, ET; Hardy, R; Hughes, A; Wills, A; Sattar, N; Deanfield, J; Kuh, D; (2015) Overweight across the life course and adipokines, inflammatory and endothelial markers at age 60-64 years: evidence from the 1946 birth cohort. International Journal of Obesity , 39 (6) pp. 1010-1018. 10.1038/ijo.2015.19. Green open access

[img]
Preview
Text
Murray_2015_overweight across the life course and adipokines_inflammatory and endothelial markers at age 60-64 years.pdf - ["content_typename_Published version" not defined]

Download (1MB) | Preview

Abstract

Background/Objectives: There is growing evidence that early development of obesity increases cardiovascular risk later in life, but less is known about whether there are effects of long-term excess body weight on the biological drivers associated with the atherosclerotic pathway, particularly adipokines, inflammatory and endothelial markers. This paper therefore investigates the influence of overweight across the life course on levels of these markers at retirement age. / Subjects/Methods: Data from the Medical Research Council National Survey of Health and Development (n=1784) were used to examine the associations between overweight status at 2, 4, 6, 7, 11, 15, 20, 26, 36, 43, 53 and 60–64 years (body mass index (BMI)greater than or equal to25 kg m−2 for adult ages and gender-specific cut-points for childhood ages equivalent to BMIgreater than or equal to25 kg m−2) and measurements of adipokines (leptin and adiponectin), inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6)) and endothelial markers (E-selectin, tissue plasminogen activator (t-PA) and von Willebrand factor) at 60–64 years. In addition, the fit of different life course models (sensitive periods/accumulation) were compared using partial F-tests. / Results: In age- and sex-adjusted models, overweight at 11 years and onwards was associated with higher leptin, CRP and IL-6 and lower adiponectin; overweight at 15 years and onwards was associated with higher E-selectin and t-PA. Associations between overweight at all ages earlier than 60–64 with leptin, adiponectin, CRP and IL-6 were reduced but remained apparent after adjustment for overweight at 60–64 years; whereas those with E-selectin and t-PA were entirely explained. An accumulation model best described the associations between overweight across the life course with adipokines and inflammatory markers, whereas for the endothelial markers, the sensitive period model for 60–64 years provided a slightly better fit than the accumulation model. / Conclusions: Overweight across the life course has a cumulative influence on adipokines, inflammatory and possibly endothelial markers. Avoidance of overweight from adolescence onwards is likely important for cardiovascular disease prevention.

Type: Article
Title: Overweight across the life course and adipokines, inflammatory and endothelial markers at age 60-64 years: evidence from the 1946 birth cohort
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/ijo.2015.19
Publisher version: http://www.nature.com/ijo/journal/v39/n6/full/ijo2...
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: science & technology, life sciences & biomedicine, endocrinology & metabolism, nutrition & dietetics, body-mass index, coronary-heart-disease, young adulthood, risk-factors, weight-gain, obesity, atherosclerosis, associations, adiponectin, adiposity
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Social Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/1465741
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item