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Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia

Gale, RE; Lamb, K; Allen, C; El-Sharkawi, D; Stowe, C; Jenkinson, S; Tinsley, S; ... Linch, DC; + view all (2015) Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia. Journal of Clinical Oncology , 33 (18) pp. 2072-2083. 10.1200/JCO.2014.59.2022. Green open access

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Abstract

To evaluate the impact of DNMT3A mutations on outcome in younger patients with cytogenetic intermediate-risk acute myeloid leukemia.

Type: Article
Title: Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1200/JCO.2014.59.2022
Publisher version: http://dx.doi.org/10.1200/JCO.2014.59.2022
Language: English
Keywords: Adolescent, Adult, Age Factors, Aged, Cohort Studies, CpG Islands, DNA (Cytosine-5-)-Methyltransferase, DNA Mutational Analysis, Exons, Female, Genotype, Humans, Incidence, Kaplan-Meier Estimate, Leukemia, Myeloid, Acute, Male, Middle Aged, Mutation, Neoplasm Recurrence, Local, Prognosis, Proportional Hazards Models, Treatment Outcome, Young Adult
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Development Bio and Cancer Prog
URI: http://discovery.ucl.ac.uk/id/eprint/1463337
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