Carbone, L;
Harris, RA;
Gnerre, S;
Veeramah, KR;
Lorente-Galdos, B;
Huddleston, J;
Meyer, TJ;
... Gibbs, RA; + view all
(2014)
Gibbon genome and the fast karyotype evolution of small apes.
Nature
, 513
(7517)
pp. 195-201.
10.1038/nature13679.
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Abstract
Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes. Here we present the assembly and analysis of a northern white-cheeked gibbon (Nomascus leucogenys) genome. We describe the propensity for a gibbon-specific retrotransposon (LAVA) to insert into chromosome segregation genes and alter transcription by providing a premature termination site, suggesting a possible molecular mechanism for the genome plasticity of the gibbon lineage. We further show that the gibbon genera (Nomascus, Hylobates, Hoolock and Symphalangus) experienced a near-instantaneous radiation ~5 million years ago, coincident with major geographical changes in southeast Asia that caused cycles of habitat compression and expansion. Finally, we identify signatures of positive selection in genes important for forelimb development (TBX5) and connective tissues (COL1A1) that may have been involved in the adaptation of gibbons to their arboreal habitat.
| Type: | Article |
|---|---|
| Title: | Gibbon genome and the fast karyotype evolution of small apes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/nature13679 |
| Publisher version: | http://dx.doi.org/10.1038/nature13679 |
| Language: | English |
| Additional information: | ©2014 Macmillan Publishers Limited. All rights reserved. This work is licensed under a Creative Commons AttributionNonCommercial-ShareAlike 3.0 Unported licence. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons. org/licenses/by-nc-sa/3.0 |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, CHROMOSOME INSTABILITY, MAXIMUM-LIKELIHOOD, GENE, RETROTRANSPOSON, BINDING, SEQUENCES, INFERENCE, MECHANISM, REGIONS, MITOSIS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1450054 |
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