Alvarez, I; Schwarzkopf, DS; Clark, CA; (2015) Extrastriate projections in human visual system: Evidence from fMRI-informed tractography. Brain Structure and Function , 220 (5) pp. 2519-2532. 10.1007/s00429-014-0799-4.

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Abstract

The human optic radiation (OR) is the main pathway for conveying visual input to occipital cortex, but it is unclear whether it projects beyond primary visual cortex (V1). In this study, we used functional MRI mapping to delineate early visual areas in 30 healthy volunteers and determined the termination area of the OR as reconstructed with diffusion tractography. Direct thalamo-cortical projections to areas V2 and V3 were found in all hemispheres tested, with a distinct anatomical arrangement of superior–inferior fiber placement for dorsal and ventral projections, respectively, and a medio-lateral nesting arrangement for projections to V1, V2 and V3. Finally, segment-specific microstructure was examined, revealing sub-fascicular information. This is to date the first in vivo demonstration of direct extrastriate projections of the OR in humans.

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