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Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.

Alg, VS; Sofat, R; Houlden, H; Werring, DJ; (2013) Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals. Neurology , 80 (23) 2154 - 2165. 10.1212/WNL.0b013e318295d751. Green open access

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Abstract

There is an urgent need to identify risk factors for sporadic intracranial aneurysm (IA) development and rupture. A genetic component has long been recognized, but firm conclusions have been elusive given the generally small sample sizes and lack of replication. Genome-wide association studies have overcome some limitations, but the number of robust genetic risk factors for IA remains uncertain.

Type: Article
Title: Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1212/WNL.0b013e318295d751
Publisher version: http://dx.doi.org/10.1212/WNL.0b013e318295d751
Language: English
Additional information: © 2013 American Academy of Neurology. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Chromosomes, Human, Pair 4, Chromosomes, Human, Pair 8, Chromosomes, Human, Pair 9, Genome-Wide Association Study, Humans, Intracranial Aneurysm, Polymorphism, Single Nucleotide, Risk Factors
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics > Clinical Epidemiology
URI: http://discovery.ucl.ac.uk/id/eprint/1396723
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