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Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults

Alfred, T; Ben-Shlomo, Y; Cooper, R; Hardy, R; Deary, IJ; Elliott, J; Harris, SE; ... HALCyon Study Team, ; + view all (2013) Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults. The Journal of Nutrition , 143 (5) 606 -612. 10.3945/jn.112.171520. Green open access

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Abstract

Several investigations have observed positive associations between good nutritional status, as indicated by micronutrients, and cognitive measures; however, these associations may not be causal. Genetic polymorphisms that affect nutritional biomarkers may be useful for providing evidence for associations between micronutrients and cognitive measures. As part of the Healthy Ageing across the Life Course (HALCyon) program, men and women aged between 44 and 90 y from 6 UK cohorts were genotyped for polymorphisms associated with circulating concentrations of iron [rs4820268 transmembrane protease, serine 6 (TMPRSS6) and rs1800562 hemochromatosis (HFE)], vitamin B-12 [(rs492602 fucosyltransferase 2 (FUT2)], vitamin D ([rs2282679 group-specific component (GC)] and β-carotene ([rs6564851 beta-carotene 15,15'-monooxygenase 1 (BCMO1)]. Meta-analysis was used to pool within-study effects of the associations between these polymorphisms and the following measures of cognitive capability: word recall, phonemic fluency, semantic fluency, and search speed. Among the several statistical tests conducted, we found little evidence for associations. We found the minor allele of rs1800562 was associated with poorer word recall scores [pooled β on Z-score for carriers vs. noncarriers: -0.05 (95% CI: -0.09, -0.004); P = 0.03, n = 14,105] and poorer word recall scores for the vitamin D-raising allele of rs2282679 [pooled β per T allele: -0.03 (95% CI: -0.05, -0.003); P = 0.03, n = 16,527]. However, there was no evidence for other associations. Our findings provide little evidence to support associations between these genotypes and cognitive capability in older adults. Further investigations are required to elucidate whether the previous positive associations from observational studies between circulating measures of these micronutrients and cognitive performance are due to confounding and reverse causality.

Type: Article
Title: Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.3945/jn.112.171520
Publisher version: http://dx.doi.org/10.3945/jn.112.171520
Language: English
Additional information: This is a free access article, distributed under terms (http://www.nutrition.org/publications/guidelines-and-policies/license/ PMCID: PMC3738233
Keywords: Adult, Aged, Aged, 80 and over, Alleles, Biological markers, Cognition, Cognition disorders, Female, Genotype, Great Britain, Hemochromatosis, Humans, Iron, Male, Mental recall, Micronutrients, Middle aged, Nutritional status, Polymorphism, Genetic, Vitamin D, Vitamin D-binding protein
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Pop, Policy and Practice Prog
URI: http://discovery.ucl.ac.uk/id/eprint/1388289
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