Ridgway, G.R. and Camara, O. and Scahill, R.I. and Crum, W.R. and Whitcher, B. and Fox, N.C. and Hill, D.L.G. (2007) Longitudinal Voxel-based morphometry with unified segmentation: evaluation on simulated Alzheimer’s disease. In: Proceedings of Medical Image Understanding and Analysis 2007. (pp. pp. 201-205). British Machine Vision Association: Malvern, UK.
![[img]](/style/images/fileicons/application_pdf.png)
| PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 999Kb |
Abstract
The goal of this work is to evaluate Voxel-Based Morphometry and three longitudinally-tailored methods of VBM.We use a cohort of simulated images produced by deforming original scans using a Finite Element Method, guided to emulate Alzheimer-like changes. The simulated images provide quite realistic data with a known pattern of spatial atrophy, with which VBM’s findings can be meaningfully compared. We believe this is the first evaluation of VBM for which anatomically-plausible ‘gold-standard’ results are available. The three longitudinal VBM methods have been implemented within the unified segmentation framework of SPM5; one of the techniques is a newly developed procedure, which shows promising potential.
| Type: | Proceedings paper |
|---|---|
| Title: | Longitudinal Voxel-based morphometry with unified segmentation: evaluation on simulated Alzheimer’s disease |
| ISBN-13: | 9781901725339 |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | http://www2.wiau.man.ac.uk/caws/Conferences/43/ |
| Language: | English |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Metabolism and Experimental Therapeutics UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases |
View download statistics for this itemArchive Staff Only: edit this record