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Modelling the inhibitory components of the Interleukin-1β network

Kelsey, J; (2012) Modelling the inhibitory components of the Interleukin-1β network. Doctoral thesis, University College London.

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Abstract

The inhibitory influences present in the interleukin-1β network are considered, and their effect on the network elucidated. IL-1β is a pro-inflammatory cytokine essential to the functioning of the immune system. The IL-1 network exhibits a complexity which has been noted by many researchers. It exists in two forms, α and β, which afforded a natural way of drawing a boundary around which part of the network was to be modelled: a choice between the α or β forms. The β form was chosen for investigation since it is known to have a higher potency than the α form. IL-1β requires the formation of a signalling ternary complex in order to trigger signalling transduction; it needs to bind with the signalling (Type-I) receptor, and for this binary complex in turn to be bound by a receptor acces- sory protein, before signalling transduction can proceed. A variety of control mechanisms which inhibit the formation of this signalling ternary process have evolved. These have been modelled using a variety of techniques.

Type:Thesis (Doctoral)
Title:Modelling the inhibitory components of the Interleukin-1β network
Language:English
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Civil, Environmental and Geomatic Engineering

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