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Modelling the inhibitory components of the Interleukin-1β network

Kelsey, J; (2012) Modelling the inhibitory components of the Interleukin-1β network. Doctoral thesis , University College London. Green open access

1348137 Kelsey PhD thesis redacted.pdf

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The inhibitory influences present in the interleukin-1β network are considered, and their effect on the network elucidated. IL-1β is a pro-inflammatory cytokine essential to the functioning of the immune system. The IL-1 network exhibits a complexity which has been noted by many researchers. It exists in two forms, α and β, which afforded a natural way of drawing a boundary around which part of the network was to be modelled: a choice between the α or β forms. The β form was chosen for investigation since it is known to have a higher potency than the α form. IL-1β requires the formation of a signalling ternary complex in order to trigger signalling transduction; it needs to bind with the signalling (Type-I) receptor, and for this binary complex in turn to be bound by a receptor acces- sory protein, before signalling transduction can proceed. A variety of control mechanisms which inhibit the formation of this signalling ternary process have evolved. These have been modelled using a variety of techniques.

Type: Thesis (Doctoral)
Title: Modelling the inhibitory components of the Interleukin-1β network
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Third party copyright material has been removed from ethesis.
UCL classification: UCL > School of BEAMS
UCL > School of BEAMS > Faculty of Engineering Science
URI: http://discovery.ucl.ac.uk/id/eprint/1348137
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