Mok, K;
Traynor, BJ;
Schymick, J;
Tienari, PJ;
Laaksovirta, H;
Peuralinna, T;
Myllykangas, L;
... Hardy, J; + view all
(2012)
Chromosome 9 ALS and FTD locus is probably derived from a single founder.
Neurobiology of Disease
, 33
(1)
209.e3 - 209.e8.
10.1016/j.neurobiolaging.2011.08.005.
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Abstract
We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease.
| Type: | Article |
|---|---|
| Title: | Chromosome 9 ALS and FTD locus is probably derived from a single founder. |
| Location: | US |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neurobiolaging.2011.08.005 |
| Publisher version: | http://dx.doi.org/10.1016/j.neurobiolaging.2011.08... |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3312749 |
| Keywords: | Amyotrophic Lateral Sclerosis, Chromosomes, Human, Pair 9, Finland, Frontotemporal Dementia, Genetic Linkage, Genome-Wide Association Study, Haplotypes, Humans, Polymorphism, Single Nucleotide |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1323119 |
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