Insights gained from palaeomicrobiology into ancient and modern tuberculosis.
Clinical Microbiology and Infection
821 - 829.
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The direct detection of ancient Mycobacterium tuberculosis molecular biomarkers has profoundly changed our understanding of the disease in ancient and historical times. Initially, diagnosis was based on visual changes to skeletal human remains, supplemented by radiological examination. The introduction of biomolecular methods has enabled the specific identification of tuberculosis in human tissues, and has expanded our knowledge of the palaeopathological changes associated with the disease. We now realize that the incidence of past tuberculosis was greater than previously estimated, as M. tuberculosis biomarkers can be found in calcified and non-calcified tissues with non-specific or no visible pathological changes. Modern concepts of the origin and evolution of M. tuberculosis are informed by the detection of lineages of known location and date.
|Title:||Insights gained from palaeomicrobiology into ancient and modern tuberculosis|
|Open access status:||An open access version is available from UCL Discovery|
|Additional information:||© 2011. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0.|
|Keywords:||Ancient DNA, lipid biomarkers, Mycobacterium tuberculosis, palaeomicrobiology, palaeopathology, induced hypertrophic osteopathy, complete genome sequence, mycobacterium-tuberculosis, molecular analysis, rib lesions, complex dna, prehistoric tuberculosis, skeletal collection, egyptian mummies, human remains|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
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