Theveneau, E;
Duband, JL;
Altabef, M;
(2007)
Ets-1 Confers Cranial Features on Neural Crest Delamination.
PLOS ONE
, 2
(11)
, Article e1142. 10.1371/journal.pone.0001142.
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Abstract
Neural crest cells (NCC) have the particularity to invade the environment where they differentiate after separation from the neuroepithelium. This process, called delamination, is strikingly different between cranial and trunk NCCs. If signalings controlling slow trunk delamination start being deciphered, mechanisms leading to massive and rapid cranial outflow are poorly documented. Here, we show that the chick cranial NCCs delamination is the result of two events: a substantial cell mobilization and an epithelium to mesenchyme transition (EMT). We demonstrate that ets-1, a transcription factor specifically expressed in cranial NCCs, is responsible for the former event by recruiting massively cranial premigratory NCCs independently of the S-phase of the cell cycle and by leading the gathered cells to straddle the basal lamina. However, it does not promote the EMT process alone but can cooperate with snail-2 (previously called slug) to this event. Altogether, these data lead us to propose that ets-1 plays a pivotal role in conferring specific cephalic characteristics on NCC delamination.
| Type: | Article |
|---|---|
| Title: | Ets-1 Confers Cranial Features on Neural Crest Delamination |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0001142 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0001142 |
| Language: | English |
| Additional information: | © 2007 Théveneau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported by the CNRS, the Université P. et M. Curie, and the Association pour la Recherche contre le Cancer (ARC 5590). ET is a recipient of doctoral fellowships from the Ministère de la Recherche and from ARC. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1298650 |
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