UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Dengue during pregnancy and live birth outcomes: a cohort of linked data from Brazil

Paixão, ES; Campbell, OM; Teixeira, MG; Costa, MC; Harron, K; Barreto, ML; Leal, MB; ... Rodrigues, LC; + view all (2019) Dengue during pregnancy and live birth outcomes: a cohort of linked data from Brazil. BMJ Open , 9 (7) , Article e023529. 10.1136/bmjopen-2018-023529. Green open access

[img]
Preview
Text
e023529.full.pdf - ["content_typename_Published version" not defined]

Download (438kB) | Preview

Abstract

OBJECTIVES: Dengue is the most common viral mosquito-borne disease, and women of reproductive age who live in or travel to endemic areas are at risk. Little is known about the effects of dengue during pregnancy on birth outcomes. The objective of this study is to examine the effect of maternal dengue severity on live birth outcomes. // DESIGN AND SETTING: We conducted a population-based cohort study using routinely collected Brazilian data from 2006 to 2012. // PARTICIPATING: We linked birth registration records and dengue registration records to identify women with and without dengue during pregnancy. Using multinomial logistic regression and Firth method, we estimated risk and ORs for preterm birth (<37 weeks' gestation), low birth weight (<2500 g) and small for gestational age (<10thcentile). We also investigated the effect of time between the onset of the disease and each outcome. // RESULTS: We included 16 738 000 live births. Dengue haemorrhagic fever was associated with preterm birth (OR=2.4; 95% CI 1.3 to 4.4) and low birth weight (OR=2.1; 95% CI 1.1 to 4.0), but there was no evidence of effect for small for gestational age (OR=2.1; 95% CI 0.4 to 12.2). The magnitude of the effects was higher in the acute disease period. // CONCLUSION: This study showed an increased risk of adverse birth outcomes in women with severe dengue during pregnancy. Medical intervention to mitigate maternal risk during severe acute dengue episodes may improve outcomes for infants born to exposed mothers.

Type: Article
Title: Dengue during pregnancy and live birth outcomes: a cohort of linked data from Brazil
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/bmjopen-2018-023529
Publisher version: http://dx.doi.org/10.1136/bmjopen-2018-023529
Language: English
Additional information: © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/ by/4.0/.
Keywords: birth outcomes, dengue, pregnancy
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Pop, Policy and Practice Prog
URI: http://discovery.ucl.ac.uk/id/eprint/10079603
Downloads since deposit
9Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item