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Hippocampal and Retrosplenial Goal Distance Coding After Long-term Consolidation of a Real-World Environment

Patai, EZ; Javadi, A-H; Ozubko, JD; O'Callaghan, A; Ji, S; Robin, J; Grady, C; ... Spiers, HJ; + view all (2019) Hippocampal and Retrosplenial Goal Distance Coding After Long-term Consolidation of a Real-World Environment. Cereb Cortex , 29 (6) pp. 2748-2758. 10.1093/cercor/bhz044. Green open access

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Abstract

Recent research indicates the hippocampus may code the distance to the goal during navigation of newly learned environments. It is unclear however, whether this also pertains to highly familiar environments where extensive systems-level consolidation is thought to have transformed mnemonic representations. Here we recorded fMRI while University College London and Imperial College London students navigated virtual simulations of their own familiar campus (>2 years of exposure) and the other campus learned days before scanning. Posterior hippocampal activity tracked the distance to the goal in the newly learned campus, as well as in familiar environments when the future route contained many turns. By contrast retrosplenial cortex only tracked the distance to the goal in the familiar campus. All of these responses were abolished when participants were guided to their goal by external cues. These results open new avenues of research on navigation and consolidation of spatial information and underscore the notion that the hippocampus continues to play a role in navigation when detailed processing of the environment is needed for navigation.

Type: Article
Title: Hippocampal and Retrosplenial Goal Distance Coding After Long-term Consolidation of a Real-World Environment
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/cercor/bhz044
Publisher version: https://doi.org/10.1093/cercor/bhz044
Language: English
Additional information: © The Author(s) 2019. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: consolidation, hippocampus, long-term memory, navigation, retrosplenial cortex
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/10075354
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