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A computed microtomography method for understanding epiphyseal growth plate fusion

Staines, KA; Madi, K; Javaheri, B; Lee, PD; Pitsillides, AA; (2018) A computed microtomography method for understanding epiphyseal growth plate fusion. Frontiers in Materials , 4 , Article 48. 10.3389/fmats.2017.00048. Green open access

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Abstract

The epiphyseal growth plate is a developmental region responsible for linear bone growth, in which chondrocytes undertake a tightly regulated series of biological processes. Concomitant with the cessation of growth and sexual maturation, the human growth plate undergoes progressive narrowing, and ultimately disappears. Despite the crucial role of this growth plate fusion “bridging” event, the precise mechanisms by which it is governed are complex and yet to be established. Progress is hindered by the current methods for growth plate visualization; these are invasive and largely rely on histological procedures. Here, we describe our non-invasive method utilizing synchrotron X-ray computed microtomography for the examination of growth plate bridging, which ultimately leads to its closure coincident with termination of further longitudinal bone growth. We then apply this method to a dataset obtained from a benchtop micro computed tomography scanner to highlight its potential for wide usage. Furthermore, we conduct finite element modeling at the micron-scale to reveal the effects of growth plate bridging on local tissue mechanics. Employment of these 3D analyses of growth plate bone bridging is likely to advance our understanding of the physiological mechanisms that control growth plate fusion.

Type: Article
Title: A computed microtomography method for understanding epiphyseal growth plate fusion
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fmats.2017.00048
Publisher version: http://doi.org/10.3389/fmats.2017.00048
Language: English
Additional information: © 2018 Staines, Madi, Javaheri, Lee and Pitsillides. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
Keywords: growth plate, mouse, bone, synchrotron, computed tomography, fusion
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/10071465
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