Tan, M;
Whitcroft, KL;
Mehta, N;
Schilder, A;
Leung, TS;
Andrews, P;
(2019)
Investigating the nasal cycle using unilateral peak nasal inspiratory flow and acoustic rhinometry minimal cross‐sectional area measurements.
Clinical Otolaryngology
, 44
(4)
pp. 518-524.
10.1111/coa.13313.
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Abstract
OBJECTIVE: To plot the nasal cycle using unilateral peak nasal inspiratory flow (UPNIF) and unilateral minimal cross-sectional area (UMCA) readings demonstrating a linear relationship in normal nasal function. Additionally, to determine how this changes in abnormal nasal function. DESIGN: A cross-sectional study measuring UPNIF and UMCA in controls demonstrating normal nasal function and in patients with nasal obstruction. SETTING: Royal National Throat Nose and Ear Hospital, London. PARTICIPANTS: 39 participants, 26 controls and 13 patients, were recruited. Controls exhibited normal nasal function with SNOT-22 <5. Patients nasal obstruction symptoms secondary to inflammation or structural abnormality with SNOT-22 >9. MAIN OUTCOME MEASURES AND RESULTS: Airflow rates and resistance values were derived from UPNIF and UMCA measurements respectively based on Poiseuille's laws. Ratios between right and left UPNIF and UMCA values were taken to adjust for confounding factors. The relationship of 1/Resistance Ratio and Airflow Rate Ratio demonstrated a linear of direct proportionality of strong correlation and statistical significance (correlation coefficient =0.76, p<0.01). This suggests that data points from controls with a normal nasal cycle lie closely along the regressed line, while those lying significantly away were shown to belong to patients with nasal dysfunction. Olfactory dysfunction appears to be a sensitive discriminator in predicting this. CONCLUSION: This study demonstrates the directly proportional relationship of 1/Resistance Ratio and Airflow Rate Ratio in normal nasal function. Furthermore, nasal pathology can be predicted if data points lie significantly outside these normal limits. Further studies are needed to validate exact normal and abnormal thresholds.
| Type: | Article |
|---|---|
| Title: | Investigating the nasal cycle using unilateral peak nasal inspiratory flow and acoustic rhinometry minimal cross‐sectional area measurements |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/coa.13313 |
| Publisher version: | https://doi.org/10.1111/coa.13313 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Nasal Cycle, Nasal Obstruction, Nasal Septum, Nose Deformities, Rhinitis, Rhinoplasty |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10068864 |
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