Molton, JS;
Thomas, BA;
Pang, Y;
Khor, LK;
Hallinan, J;
Naftalin, CM;
Totman, JJ;
... Paton, NI; + view all
(2019)
Sub-clinical abnormalities detected by PET/MRI in household tuberculosis contacts.
BMC Infectious Diseases
, 19
(1)
, Article 83. 10.1186/s12879-019-3705-0.
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Abstract
BACKGROUND: The understanding of early events following TB exposure is limited by traditional tests that rely on detection of an immune response to infection, which is delayed, or on imaging tests with low sensitivity for early disease. We investigated for evidence of lung abnormalities in heavily exposed TB contacts using PET/MRI. METHODS: 30 household contacts of 20 index patients underwent clinical assessment, IGRA testing, chest x-ray and PET/MRI scan using 18-F-FDG. MRI images were examined by a radiology/nuclear medicine dual-qualified physician using a standardised report form, while PET/MRI images were examined independently by another radiology/nuclear medicine dual-qualified physician using a similar form. Standardised uptake value (SUV) was quantified for each abnormal lesion. RESULTS: IGRA was positive in 40%. PET/MRI scan was abnormal in 30%, predominantly FDG uptake in hilar or mediastinal lymph nodes and lung apices. We did not identify any relationship between PET/MRI findings and degree of exposure or IGRA status. CONCLUSION: PET-based imaging may provide important insights into the natural history following exposure to TB that may not be available from traditional tests of TB immune response or imaging. The clinical significance of the abnormalities is uncertain and merits further investigation in longitudinal studies.
| Type: | Article |
|---|---|
| Title: | Sub-clinical abnormalities detected by PET/MRI in household tuberculosis contacts |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s12879-019-3705-0 |
| Publisher version: | https://doi.org/10.1186/s12879-019-3705-0 |
| Language: | English |
| Additional information: | Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| Keywords: | Exposure, MRI, PET-scan, Tuberculosis |
| UCL classification: | UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10067006 |
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