UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Dynamic causal modelling of seizure activity in a rat model

Papadopoulou, M; Cooray, G; Rosch, R; Moran, R; Marinazzo, D; Friston, K; (2017) Dynamic causal modelling of seizure activity in a rat model. NeuroImage , 146 pp. 518-532. 10.1016/j.neuroimage.2016.08.062. Green open access

[img]
Preview
Text
Rosch_Dynamic causal modelling of seizure activity in a rat model_AAM.pdf - ["content_typename_Accepted version" not defined]

Download (2MB) | Preview

Abstract

This paper presents a physiological account of seizure activity and its evolution over time using a rat model of induced epilepsy. We analyse spectral activity recorded in the hippocampi of three rats who received kainic acid injections in the right hippocampus. We use dynamic causal modelling of seizure activity and Bayesian model reduction to identify the key synaptic and connectivity parameters that underlie seizure onset. Using recent advances in hierarchical modelling (parametric empirical Bayes), we characterise seizure onset in terms of slow fluctuations in synaptic excitability of specific neuronal populations. Our results suggest differences in the pathophysiology – of seizure activity in the lesioned versus the non-lesioned hippocampus – with pronounced changes in excitation-inhibition balance and temporal summation on the lesioned side. In particular, our analyses suggest that marked reductions in the synaptic time constant of the deep pyramidal cells and the self-inhibition of inhibitory interneurons (in the lesioned hippocampus) are sufficient to explain changes in spectral activity. Although these synaptic changes are consistent over rats, the resulting electrophysiological phenotype can be quite diverse.

Type: Article
Title: Dynamic causal modelling of seizure activity in a rat model
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuroimage.2016.08.062
Publisher version: https://doi.org/10.1016/j.neuroimage.2016.08.062
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/10056008
Downloads since deposit
51Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item