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Subretinal mononuclear phagocytes induce cone segment loss via IL-1β

Eandi, CM; Charles Messance, H; Augustin, S; Dominguez, E; Lavalette, S; Forster, V; Hu, SJ; ... Sennlaub, F; + view all (2016) Subretinal mononuclear phagocytes induce cone segment loss via IL-1β. eLife , 5 , Article e16490. 10.7554/eLife.16490. Green open access

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Abstract

Photo-transduction in cone segments (CS) is crucial for high acuity daytime vision. For ill-defined reasons, CS degenerate in retinitis pigmentosa (RP) and in the transitional zone (TZ) of atrophic zones (AZ), which characterize geographic atrophy (GA). Our experiments confirm the loss of cone segments (CS) in the TZ of patients with GA and show their association with subretinal CD14(+)mononuclear phagocyte (MP) infiltration that is also reported in RP. Using human and mouse MPs in vitro and inflammation-prone Cx3cr1(GFP/GFP) mice in vivo, we demonstrate that MP-derived IL-1β leads to severe CS degeneration. Our results strongly suggest that subretinal MP accumulation participates in the observed pathological photoreceptor changes in these diseases. Inhibiting subretinal MP accumulation or Il-1β might protect the CS and help preserve high acuity daytime vision in conditions characterized by subretinal inflammation, such as AMD and RP.

Type: Article
Title: Subretinal mononuclear phagocytes induce cone segment loss via IL-1β
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.16490
Publisher version: https://doi.org/10.7554/eLife.16490
Language: English
Additional information: Copyright © Eandi et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
Keywords: age-related macular degeneration, human, human biology, interleukin, macrophages, medicine, mouse, neuroscience, outer segments, retinitis pigmentosa, subretinal space, Animals, Geographic Atrophy, Humans, Interleukin-1beta, Mice, Phagocytes, Retina, Retinal Cone Photoreceptor Cells
URI: http://discovery.ucl.ac.uk/id/eprint/10054204
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