Mazlin, V;
Xiao, P;
Dalimier, E;
Grieve, K;
Irsch, K;
Sahel, J;
Fink, M;
(2018)
In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography.
In:
Proceedings of the SPIE 10474, Ophthalmic Technologies XXVIII.
SPIE: San Francisco, California, United States.
Preview |
Text
104740S.pdf - Published Version Download (538kB) | Preview |
Abstract
Despite obvious improvements in visualization of the in vivo cornea through the faster imaging speeds and higher axial resolutions, cellular imaging stays unresolvable task for OCT, as en face viewing with a high lateral resolution is required. The latter is possible with FFOCT, a method that relies on a camera, moderate numerical aperture (NA) objectives and an incoherent light source to provide en face images with a micrometer-level resolution. Recently, we for the first time demonstrated the ability of FFOCT to capture images from the in vivo human cornea1. In the current paper we present an extensive study of appearance of healthy in vivo human corneas under FFOCT examination. En face corneal images with a micrometer-level resolution were obtained from the three healthy subjects. For each subject it was possible to acquire images through the entire corneal depth and visualize the epithelium structures, Bowman's layer, sub-basal nerve plexus (SNP) fibers, anterior, middle and posterior stroma, endothelial cells with nuclei. Dimensions and densities of the structures visible with FFOCT, are in agreement with those seen by other cornea imaging methods. Cellular-level details in the images obtained together with the relatively large field-of-view (FOV) and contactless way of imaging make this device a promising candidate for becoming a new tool in ophthalmological diagnostics.
| Type: | Proceedings paper |
|---|---|
| Title: | In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography |
| Event: | SPIE 10474, Ophthalmic Technologies XXVIII |
| ISBN-13: | 9781510614338 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/12.2288947 |
| Publisher version: | http://doi.org/10.1117/12.2288947 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10053723 |
Archive Staff Only
 |
View Item |
