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Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link

Ramos-Cejudo, J; Wisniewski, T; Marmar, C; Zetterberg, H; Blennow, K; de Leon, MJ; Fossati, S; (2018) Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link. [Review]. EBioMedicine , 28 pp. 21-30. 10.1016/j.ebiom.2018.01.021. Green open access

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Abstract

Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological disorders, whose complex relationship is not completely understood. Cerebrovascular pathology, a key element in both conditions, could represent a mechanistic link between Aβ/tau deposition after TBI and the development of post concussive syndrome, dementia and chronic traumatic encephalopathy (CTE). In addition to debilitating acute effects, TBI-induced neurovascular injuries accelerate amyloid β (Aβ) production and perivascular accumulation, arterial stiffness, tau hyperphosphorylation and tau/Aβ-induced blood brain barrier damage, giving rise to a deleterious feed-forward loop. We postulate that TBI can initiate cerebrovascular pathology, which is causally involved in the development of multiple forms of neurodegeneration including AD-like dementias. In this review, we will explore how novel biomarkers, animal and human studies with a focus on cerebrovascular dysfunction are contributing to the understanding of the consequences of TBI on the development of AD-like pathology.

Type: Article
Title: Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ebiom.2018.01.021
Publisher version: http://doi.org/10.1016/j.ebiom.2018.01.021
Language: English
Additional information: Copyright © 2018 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Keywords: Traumatic brain injury, Alzheimer's disease, Cerebrovascular pathology, Biomarkers, Aβ, Tau
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/10051884
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